Radiation-Induced Olfactory Neuroblastoma
نویسندگان
چکیده
Olfactory neuroblastoma (ONB) is a rare, malignant neuroendocrine tumor with potential to develop outside the normal means and distribution of olfactory neuroepithelium. With four published cases, we present a patient with a frontal sinus ONB invading the dura after receiving whole brain radiation for non-Hodgkin Lymphoma 20 years before. Imaging and biopsy revealed a frontal sinus malignant neuroendocrine neoplasm with posterior table and dural involvement. She underwent a combined craniofacial resection with adjuvant stereotactic radiosurgery. She subsequently developed metastatic disease. The element of radiation introduced a variable that undoubtedly affected her loco regional control and overall survival.
منابع مشابه
Improved survival following surgery and radiation therapy for olfactory neuroblastoma: analysis of the SEER database
BACKGROUND Olfactory Neuroblastoma is a rare malignant tumor of the olfactory tract. Reports in the literature comparing treatment modalities for this tumor are limited. METHODS The SEER database (1973-2006) was queried by diagnosis code to identify patients with Olfactory Neuroblastoma. Kaplan-Meier was used to estimate survival distributions based on treatment modality. Differences in survi...
متن کاملOlfactory neuroblastoma: the 22-year experience at one comprehensive cancer center.
BACKGROUND Olfactory neuroblastoma (ONB) is a rare tumor arising from the olfactory neuroepithelium. There is no universally accepted staging system, and treatment approaches lack uniformity. We present one institution's experience with this tumor and the results of therapy. METHODS Thirty patients treated for ONB at The University of Texas M. D. Anderson Cancer Center between 1979 and 2002 w...
متن کاملOlfactory neuroblastoma: a case report and review of the literature.
Malignant tumors of the nasal cavity are rare. We report the case of an elderly woman who consulted us with a 4-year history of progressive nasal obstruction, occasional epistaxis, facial pain, and watering of the eyes. A diagnosis of olfactory neuroblastoma was established by histopathology and confirmed by immunohistochemistry. On staging, the mass was classified as a Kadish stage B tumor. Th...
متن کاملOlfactory Neuroblastoma Treated by Endoscopic Surgery Followed by Combined External Beam Radiation and Gamma Knife for Optic Nerve and Chiasm Sparing: A Case Report
We describe the multimodality treatment regimen of a 53-year-old man diagnosed with olfactory neuroblastoma (Kadish stage C) in the right nasal cavity extending into the ethmoid sinus and across the cribriform plate. Endoscopic surgery for tumor resection was followed by a combination of external beam radiotherapy and stereotactic radiosurgery boost with concurrent chemotherapy. The novel combi...
متن کاملEsthesioneuroblastoma: one of the causes of proptosis
Esthesioneuroblatoma (Olfactory neuroblastoma) is a rare malignant neoplasm arising from the olfactory epithelium with bimodal age distribution between with first peak in second decades and second peak in sixth decade. Proptosis due to esthesioneuroblastoma is one of the rare causes. They have a long natural history characterized by frequent local or regional recurrence. Computed tomography and...
متن کامل